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KMID : 1123920030170020503
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Korean Journal of Oriental Physiology and Pathology
2003 Volume.17 No. 2 p.503 ~ p.509
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Effects of Mangeum-tang and Gamimangeum-tang on the Cultured Spinal Dorsal Root Ganglion Cells
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Choi Gyu-Seon
Kwon Young-Dal
Song Yung-Sun
Yun Sang-Hak
Yeom Seung-Ryong
Lee Su-Kyung
Shin Byung-Cheul
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Abstract
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The purpose of this study is to examine the toxic effects caused by xanthine oxidase/hypoxanthine (XO/HX) and the effects of herbal extracts such as Mangeum-tang (萬金湯: MGT) and Gamimangeum-tang (加味萬金湯: GMGT) on the treatment of the toxic effects. The results of these experiments were XO/HX, an oxygen radical-generating system, decreased the survival rates of the cultured cells on XTT assay, the amount of DNA syntheses, and the amount of neurofilaments, and increased c-fos positive cells, MGT and GMGT have the efficacy of increasing the survival rates of the cultured cells by increasing the amount of neurofilaments and DNA synthesis and decreasing the c-fos positive cells damaged by XO/HX, From the above results, it is suggested that MGT and GMGT have marked efficacy as a treatment for the damages caused by the XO/HX-mediated oxidative stress. And MGT and GMGT are thought to have certain pharmacological effects.
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KEYWORD
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Mangeum-tang(萬金湯), Gamimangeum-tang(加味萬金湯), Xanthine Oxidase (XO), Hypoxanthine (HX), XTT, Neurofilament, DNA synthesis, c-fos
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